This reference design is a digitally programmable non-isolated power supply for powering ultrasound transmit circuit. It uses flyback power supply topology with the a single transformer to generate dual programmable high voltage (HV) up to the absolute value of 100 V. This design is targeted for low-power portable ultrasound scanners. The design can deliver a maximum continuous power of 25 W with 12.5 W each on individual rails. The HV rails are programmable from 0 V to ±100 V through a set DC voltages. The programmability through DAC can be implemented using 12-bit DACs which can be referenced from reference design TIDA-01352. All the power supply rails are capable of synchronizing to a master clock. This design is scalable and modular allowing the same supply to be duplicated or removed: depending on number of channels and number of pulser levels.