This reference design is a simplified architecture for generating an isolated power supply for isolated amplifiers for measuring isolated voltages and currents. A fully integrated DC/DC converter with reinforced isolation operating from a 5-V input with configurable 5-V or 5.4-V output (headroom for low dropout regulator (LDO)) generates the isolated power. Shunts that are interfaced to ±50-mV input range isolation amplifiers configured as channel isolated inputs measure the current. Potential divider output interfaced to ±250-mV or ±12-V input range isolation amplifiers configured as group isolated inputs measure the voltage. The outputs of the isolation amplifiers interface directly to 24-bit delta sigma analog-to-digital converter (ADC) or are scaled to ±10 V using gain amplifiers and interfaced to 16-bit SAR ADC for performance evaluation. On-board digital diagnostics improves reliability and enhances system performance.